From 1987 to 1995, Saget starred on Full House. He played Danny Tanner, a widowed father who has his brother-in-law Jesse Katsopolis (John Stamos) and best friend Joey Gladstone (Dave Coulier) move in to help him raise his three daughters: D.J. Tanner (Candace Cameron Bure), Stephanie Tanner (Jodie Sweetin) and Michelle Tanner (Ashley Olsen and Mary-Kate Olsen).
After the news broke, Stamos took to Twitter to mourn Saget's death. "I am broken. I am gutted. I am in complete and utter shock," he wrote. "I will never ever have another friend like him. I love you so much Bobby."
Saget also hosted America's Funniest Home Videos from 1989 to 1997. "We are saddened to hear about the passing of the great @bobsaget," the show's official Twitter account wrote in a tribute. "Our thoughts are with his friends and family at this time."
Danny Tanner wasn't the only fatherly role Saget played. From 2001 to 2002, Saget portrayed Matt Stewart, a widowed dad who raises his daughters Sarah (Kat Dennings) and Emily (Brie Larson) with some assistance from his father (Jerry Adler) and is also a teacher at Sarah's high school.
"I'm speechless," Dennings wrote on Instagram. "Bob Saget was the best. So kind. I was his TV daughter for one season and he was generous, protective, caring and wonderful. He talked about his kids constantly. Rest In Peace."
From 2005 to 2014, Saget served as the narrator on How I Met Your Mother and provided the voice of Josh Radnor's character Ted Mosby in the future.
During a 2014 interview with Larry King, Saget said "it was a beautiful thing to have been involved in it" and recalled being offered the role while he was working on a play in New York.
"I did it immediately because I read it and it was a love letter. It was a relationship show," he said. "And it's been an amazing thing that I forget, people say, 'I love your show.' I say, 'Well, it's their show 'cause they're the most talented actors that made this happen.'"
While he wasn't a regular member of the cast, Saget did make a few cameos on Entourage, including in 2005, 2009 and 2010 episodes and the 2015 movie. He also made brief appearances on other shows, including a 2018 episode of Shameless.
Saget played Steve Patterson on the 2009 sitcom Surviving Suburbia. The show followed the lives of Steve, his wife Anne (Cynthia Stevenson) and their children Henry (Jared Kusnitz) and Courtney (Genevieve Hannelius) and their dynamic with their neighbors.
Over the years, Saget starred in a number of stand-up specials, including Bob Saget: Zero to Sixty (2017) and Bob Saget: That Ain't Right (2007). His 2013 special, Bob Saget: That's What I'm Talkin' About, was nominated for a Grammy in the Best Comedy Album category.
In 2016, Saget reprised his role as Danny Tanner on the spinoff series Fuller House. The show followed D.J., now an adult and recent widow, as she raises her three sons with her sister Stephanie and BFF Kimmy (Andrea Barber). The show ended in 2020.
"I don't know what to say," Bure tweeted. "I have no words. Bob was one of the best humans beings I've ever known in my life. I loved him so much."